Sepiatec's Sepbox concept is based on a patented combination of High Performance Liquid Chromatography (HPLC) together with Solid Phase Extraction (SPE). With this platform technology a large number of samples can be efficiently processed. Up to 600 samples for HTS can be obtained with a maximum of purity and more than 90% recovery rate using 2-dimensional separation, both for polar and non-polar substances. For highly polar substances an optional polar setup can be integrated.