SFC Technology for Preparative Chiral Separation

SFC Technology for Preparative Chiral Separation

The famous “Thalidomide Incident” in the 1960’s, which lead to the birth of about 12,000 defected babies, has raised worldwide attention to the importance of identification and separation for chiral drugs. This incident further urged FDA to impose strict requirements on submitting chirality research data for new drug application. Such data include the separation method, efficacy, toxicity and side effects of a chiral drug for both the pure enantiomer and racemic form. Because of the strong influence of chirality on drug efficacy and safety, an efficient and effective separation of the chiral structures is inevitably necessary throughout the drug development process. 

Among various chiral separation techniques, chromatographic approach is by far the predominant one. Chromatographic chiral separation method includes thin layer chromatography (TLC), gas chromatography (GC), high performance capillary electrophoresis (HPCE), high performance liquid chromatography (HPLC) and supercritical fluid chromatography (SFC). Drawbacks of these methods include limited separating ability by TLC, irreversible damage on thermally unstable compounds caused by high separating temperature during GC, limited solvent options offered by HPCE, and large organic solvents consumption when using HPLC. On the other hand, SFC offers advantages such as rapid analysis, good resolution, high sample load and minimal organic solvent consumption, making it the superior chiral separating method. 

With years of success in developing preparative HPLC system, Sepiatec launched the latest Prep SFC 100 system, endeavor to delivering the best solution for preparative separation of chiral compounds.

  • Sepiatec
    Prep SFC 100


Sepiatec Prep SFC 100 system offers rapid and easy preparative chiral separation for a diverse range of compounds such as natural product, synthetic products and by-products, and even heat sensitive compounds. Substantial application results show that the Sepiatec Prep SFC 100 system has high recovery efficiency and reproducibility, meeting all the needs for research, production and quality control.

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