DBS
Take the tedium out of Dried Blood Spot analysis
DBS
Automated Dried Blood Spot (DBS) Analysis System for LC-MS
Paul Abu-Rabie, GlaxoSmithKline, Bioanalytical Science and Development, UK
Drug development requires the screening of numerous blood samples to determine the bioavailability, clearance, and safety margins of a pharmaceutical substance in the body.
The surge in interest in DBS techniques for supporting pharmaceutical exposure studies is due to the many advantages it offers over conventional plasma sampling.
Dried Blood Spot (DBS) analysis offers significant advantages over traditional liquid sampling techniques: it is less invasive, and requires smaller samples which can be stored for a longer period, often at ambient temperatures, and present less risk of infection. However, the preparation, storage and management of large numbers of DBS samples for diagnostic TLC analysis presents a formidable challenge to researchers.
By facilitating the automated extraction of DBS cards, the CAMAG DBS-MS500 makes it easy to screen many blood samples automatically and reliably within a short period. As compared with conventional time-consuming manual collection and analysis of blood or plasma samples, it greatly simplifies the blood collection process and reduces costs and risks, making it a highly efficient sample preparation instrument for LC-MS / MS (Mass Spectrometry) analysis.
- Fully automated rapid handling of up to 500 DBS cards with card extraction in just 3 minutes at ambient temperatures.
- Precise optical DBS card spot positioning by the MS500’s reliable robotics and newly-developed gripping tool.
- Integrated barcode reading device for accurate card identification.
- Automated internal standard (IS) application module can be applied directly before LC-MS analysis.
- Reliable wash station eliminates carry-over concerns.
- Easy integration with any LC-MS system provides high flexibility and facilitates convenient use in a wide variety of lab environments.
- Spot regularity measurement and monitoring
- Flexible sample loop, free choice of multiple solvents
- Modular design allows for easy extension and upgrade110 x 80 x 60cm (w x d x h); additional space of 10cm for ventilation and height of 30cm for solvent bottle placement required
- Net weight 120kg
- Touch screen display for selecting and editing methods and setting parameters
- Communication with LC-MS: contact closure, optional Ethernet communication
- Pre-clinical and clinical bioanalysis
- Paediatric studies
- Therapeutic Drug Monitoring
- Newborn Screening
- Toxicology studies