Crystalline RR

Real-time Raman capability in a sophisticated parallel crystallizer

Parallel Crystallizer with Raman Probe

In addition to providing all the benefits of Technobis’s Crystalline SE (Standard Edition), the advanced Crystalline RR (Raman Ready) incorporates the real-time Raman function. It monitors chemical and morphological changes, providing powerful capabilities in developing and optimizing crystallization processes.

Like other models in the Crystalline range, the RR is a compact yet sophisticated parallel crystallizer suitable for crystallization process development and optimization across a broad range of industries. Its intuitive control and analysis software gives unparalleled access to real-time information on experiments.

  • 4 parallel real-time non-intrusive Raman probes perform real-time monitoring of chemical and morphological changes.
  • 8 independently programmable reactors with stir bar and/or overhead stirring make it possible to study the effect of different solvents or counter-ions in a simple and easy fashion.
  • 8 blocks with independently programmable temperature and stirring control with stir bar enable one system to be used simultaneously by several operators.
  • 8 independent non-invasive turbidity probes provide real-time turbidity measurements while avoiding cross-contamination.
  • ml-scale reaction saves on samples while compact ergonomic design saves valuable laboratory space.
  • Range of crystallization techniques (e.g. cooling, evaporation, anti-solvent addition, etc.) supported.
  • Correlation of Raman spectra with temperature profiles and turbidity signals
  • Software interface for spectroscopic analysis
  • Precise temperature control (0.1 °C) and fast heating / cooling rate
  • ml-scale refluxing capability
  • ml-scale slow evaporation with N2 flow
  • ml-scale seeding capability
  • Software for fast report export
  • Can mix even the most viscous materials in a controlled fashion
  • Feedback control allows response to crystallization events during the temperature cycle
  • Expandable to online observation of morphology
  • Process development and optimization
  • Monitoring chemical reactions
  • Monitoring changes in crystal form
  • Polymorph/solvate/hydrate/co-crystal screening
  • Looking for less stable intermediates
  • Controlling growth of certain polymorphs
  • Fast solubility curve and MSZW determination
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